A model of the iron responsive element RNA hairpin loop structure determined from NMR and thermodynamic data.

@article{Laing1996AMO,
  title={A model of the iron responsive element RNA hairpin loop structure determined from NMR and thermodynamic data.},
  author={L G Laing and Kathleen B Hall},
  journal={Biochemistry},
  year={1996},
  volume={35 42},
  pages={13586-96}
}
The iron responsive element (IRE) is a conserved RNA structure that is found in the 5' UTR of ferritin mRNA and in the 3' UTR of transferrin receptor mRNA. It is the binding site of the iron responsive protein (IRP), and the interaction is part of the regulation of cellular iron metabolism. The IRE six-nucleotide hairpin loop, 5'C1A2G3U4G5N6, is conserved in sequence, and mutations have shown that it is required for IRP binding. On the basis of the thermodynamic and NMR experiments utilized… CONTINUE READING