A model of the complex response of Staphylococcus aureus to methicillin.


It is widely accepted that beta-lactam antimicrobials cause cell death through a mechanism that interferes with cell wall synthesis. Later studies have also revealed that beta-lactams modify the autolysis function (the natural process of self-exfoliation of the cell wall) of cells. The dynamic equilibrium between growth and autolysis is perturbed by the… (More)
DOI: 10.1016/j.jtbi.2008.12.003


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