A model of the cell-autonomous mammalian circadian clock.

  title={A model of the cell-autonomous mammalian circadian clock.},
  author={Henry P Mirsky and Andrew Chi-Yeu Liu and David K. Welsh and Steve A Kay and Francis J. Doyle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 27},
Circadian timekeeping by intracellular molecular clocks is evident widely in prokaryotes and eukaryotes. The clockworks are driven by autoregulatory feedback loops that lead to oscillating levels of components whose maxima are in fixed phase relationships with one another. These phase relationships are the key metric characterizing the operation of the clocks. In this study, we built a mathematical model from the regulatory structure of the intracellular circadian clock in mice and identified… CONTINUE READING

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