A model of slow plateau-like oscillations based upon the fast Na+ current in a window mode

Abstract

Divalent ions, which block Ca currents, combined with partial block of outward currents give rise to slow plateau-like oscillations (10}50 s period) with long duration plateaus and long inter-plateau intervals in leech heart interneurons (Opdyke, Calabrese, J. Comp. Physiol. 175 (1994) 781}789.) We present a simpli"ed mathematical model that replicates the main characteristics of these observations and suggests an underlying biophysical mechanism. A model containing transient Na current (I ), leakage and outward currents can generate oscillations with long plateau duration. The plateaus arise from a window mode of I and do not require noninactivating Na current (I ). The long inter-plateau intervals are produced reliably after including I . 2001 Elsevier Science B.V. All rights reserved.

DOI: 10.1016/S0925-2312(01)00414-3

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Cite this paper

@article{Cymbalyuk2001AMO, title={A model of slow plateau-like oscillations based upon the fast Na+ current in a window mode}, author={Gennady S. Cymbalyuk and Ronald L. Calabrese}, journal={Neurocomputing}, year={2001}, volume={38-40}, pages={159-166} }