A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations

@article{Noble1984AMO,
  title={A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations},
  author={Denis Noble and S. J. Noble},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1984},
  volume={222},
  pages={295 - 304}
}
  • D. Noble, S. Noble
  • Published 1984
  • Chemistry, Medicine
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
DiFrancesco & Noble’s (1984) equations (Phil. Trans. R. Soc. Lond. B (in the press.)) have been modified to apply to the mammalian sino-atrial node. The modifications are based on recent experimental work. The modified equations successfully reproduce action potential and pacemaker activity in the node. Slightly different versions have been developed for peripheral regions that show a maximum diastolic potential near — 75 mV and for central regions that do not hyperpolarize beyond —60 to —65 mV… Expand
Comparative study of rabbit sino-atrial node cell models
Abstract This paper compares recent mathematical models of rabbit sino-atrial node pacemaker cell activity [Cellular and Neuronal Oscillators, Dekker, New York, 1989, p. 59; Am. J. Physiol. 266Expand
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  • S. Demir
  • Physics
  • Proceedings of the 1998 2nd International Conference Biomedical Engineering Days
  • 1998
Spontaneous pacing is an intrinsic property of the pacemaker cells in the sinoatrial node (SAN) of the heart. Models of the SAN cells have been developed over the last two decades to simulate theExpand
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  • Chemistry
  • 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 1992
The effect of acetylcholine (ACh) on ionic currents responsible for pacemaking activity at the sinoatrial node was investigated using a mathematical model based on the DiFrancesco Noble equations.Expand
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TLDR
This compartmental model of the single rabbit sinoatrial node (SAN) cell is applicable over the full range of intensity and pattern of vagal input and can offer biophysically based explanations for many of the phenomena associated with the autonomic control of cardiac pacemaking. Expand
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TLDR
This model provides acceptable fits to voltage-clamp and action potential data and can be used to seek biophysically based explanations of the electrophysiological activity in the rabbit sinoatrial node cell. Expand
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TLDR
The results show that the major chronotropic effects of vagal stimulation on the SA cell membrane can be explained in terms of the ACh-activated potassium current, which cannot contribute to any long lasting dynamics of the cardiac period response. Expand
A model of cardiac electrical activity incorporating ionic pumps and concentration changes.
  • D. DiFrancesco, D. Noble
  • Physics, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1985
TLDR
The model takes account of extensive developments in experimental work since the formulation of the M.N. Noble equations, and successfully account for all the properties formerly attributed to i $\_{K2}$ , as well as giving more complete descriptions of i $\_K$ and i $\-K$ . Expand
A model of the single atrial cell: relation between calcium current and calcium release
  • Y. Earm, D. Noble
  • Chemistry, Medicine
  • Proceedings of the Royal Society of London. B. Biological Sciences
  • 1990
TLDR
The hypothesis that calcium release from the sarcoplasmic reticulum in cardiac muscle is induced by rises in free cytosolic calcium allows the possibility that the release could be at least partly regenerative, and it is important to allow for the buffering properties of calcium indicators when investigating the correlation between calcium current and calcium release. Expand
Pacemaker mechanism of porcine sino-atrial node cells.
TLDR
The density and the kinetics of I(K) contribute, in part, to the different heart rates of various species as well as of the voltage clamp recordings. Expand
Phase response characteristics of sinoatrial node cells
TLDR
The detailed analysis of the ionic mechanisms involved in its resetting behavior of sinoatrial node cell models provides new insight into the dynamics and physiology of excitation of the sino atrial node of the heart. Expand
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The properties of the slow inward current, isi in the sino-atrial (s.a.a.) node of the rabbit have been investigated using two microelectrodes to apply voltage clamp to small, spontaneously beating, preparations and it is found that the positive staircases can be closely simulated by a model which incorporates slower processes (suggested Na-Ca exchange current) in the totalIsi in addition to the gated current component. Expand
Implications of the Re-Interpretation of iK2 for the Modelling of the Electrical Activity of Pacemaker Tissues in the Heart
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It was strongly suggested that the pacemaker depolarization in the S-A node cell is mainly due to a gradual increase of iS during diastole, and that the contribution of iK is much less compared to the potassium current iK2 in the Purkinje fiber pacemakerdepolarization. Expand
A model of cardiac electrical activity incorporating ionic pumps and concentration changes.
  • D. DiFrancesco, D. Noble
  • Physics, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1985
TLDR
The model takes account of extensive developments in experimental work since the formulation of the M.N. Noble equations, and successfully account for all the properties formerly attributed to i $\_{K2}$ , as well as giving more complete descriptions of i $\_K$ and i $\-K$ . Expand
The Relative Contributions of Various Time-Dependent Membrane Currents to Pacemaker Activity in the Sino Atrial Node
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TLDR
The Appendix contains a brief consideration of the experimental and theoretical basis for the method of exponential separation of outward current components in the presence of the extracellular potassium accumulation that inevitably accompanies the flow of outward membrane current. Expand
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TLDR
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TLDR
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TLDR
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