A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene.

@article{Wickliffe2003AMO,
  title={A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene.},
  author={Jeffrey K Wickliffe and Marinel M Ammenheuser and James J Salazar and S. Z. Abdel-Rahman and Darlene A Hastings-Smith and Edward M. Postlethwait and R. Stephen Lloyd and Jonathan B Ward},
  journal={Environmental and molecular mutagenesis},
  year={2003},
  volume={42 2},
  pages={
          106-10
        }
}
The specific role that polymorphisms in xenobiotic metabolizing enzymes play in modulating sensitivity to 1,3-butadiene (BD) genotoxicity has been relatively unexplored. The enzyme microsomal epoxide hydrolase (mEH) is important in detoxifying the mutagenic epoxides of BD (butadiene monoepoxide [BDO], butadiene diepoxide [BDO(2)]). Polymorphisms in the human mEH gene appear to affect the function of the enzyme. We exposed mice with normal mEH activity (WT) and knockout mice without mEH activity… CONTINUE READING