A model of segmental duplication formation in Drosophila melanogaster.

  title={A model of segmental duplication formation in Drosophila melanogaster.},
  author={Anna-Sophie Fiston-Lavier and Dominique Anxolab{\'e}h{\`e}re and Hadi Quesneville},
  journal={Genome research},
  volume={17 10},
Segmental duplications (SDs) are low-copy repeats of DNA segments that have long been recognized to be involved in genome organization and evolution. But, to date, the mechanism of their formation remains obscure. We propose a model for SD formation that we name "duplication-dependent strand annealing" (DDSA). This model is a variant of the synthesis-dependent strand annealing (SDSA) model--a double-strand break (DSB) homologous repair model. DSB repair in Drosophila melanogaster genome usually… CONTINUE READING
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