A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model.

@article{Li2012AMO,
  title={A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model.},
  author={Jing Li and Babbette LaMarca and Jane F. Reckelhoff},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={303 1},
  pages={H1-8}
}
Preeclampsia is defined as new-onset hypertension with proteinuria after 20 wk gestation and is hypothesized to be due to shallow trophoblast invasion in the spiral arteries thus resulting in progressive placental ischemia as the fetus grows. Many animal models have been developed that mimic changes in maternal circulation or immune function associated with preeclampsia. The model of reduced uterine perfusion pressure in pregnant rats closely mimics the hypertension, immune system abnormalities… CONTINUE READING