A model of human immunodeficiency virus infection in T helper cell clones.

@article{McLean1990AMO,
  title={A model of human immunodeficiency virus infection in T helper cell clones.},
  author={Angela R. McLean and T. B. Kirkwood},
  journal={Journal of theoretical biology},
  year={1990},
  volume={147 2},
  pages={177-203}
}
We present a mathematical model of the activation and proliferation of a clone of T helper cells in response to a replicating antigen. This is able to show types of behaviour akin to persistent infection and to immune memory. This model is expanded to include the infection and destruction of activated T helper cells by human immunodeficiency virus and the growth of a population of circulating human immunodeficiency virus. The resulting model is used to investigate the circumstances under which… CONTINUE READING

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