A model of cell inactivation by alpha-particle internal emitters.

  title={A model of cell inactivation by alpha-particle internal emitters.},
  author={John L. Humm and Lee M. Chin},
  journal={Radiation research},
  volume={134 2},
Tumor-associated antibodies labeled with 131I and 90Y have been used in the treatment of malignant disease with some success. The use of alpha-particle-emitting radionuclides as radiolabels offers potential advantages over beta-particle sources. The short range in tissue (< 100 microns) and the high linear energy transfer associated with alpha-particle emitters will result in a more concentrated deposition of energy at the site of radionuclide decay. Thus, if radiolabeled antibodies can be… CONTINUE READING
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