A model of cardiac electrical activity incorporating ionic pumps and concentration changes.

@article{DiFrancesco1985AMO,
  title={A model of cardiac electrical activity incorporating ionic pumps and concentration changes.},
  author={Dario DiFrancesco and Denis Noble},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1985},
  volume={307 1133},
  pages={
          353-98
        }
}
  • D. DiFrancesco, D. Noble
  • Published 1985
  • Physics, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Equations have been developed to describe cardiac action potentials and pacemaker activity. The model takes account of extensive developments in experimental work since the formulation of the M.N.T. (R. E. McAllister, D. Noble and R. W. Tsien, J. Physiol., Lond. 251, 1-59 (1975)) and B.R. (G. W. Beeler and H. Reuter, J. Physiol., Lond. 268, 177-210 (1977)) equations. The current mechanism i $\_{K2}$ has been replaced by the hyperpolarizing-activated current, i $\_f$ . Depletion and accumulation… Expand
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