A model of calcium regulation in smooth muscle cell.

  title={A model of calcium regulation in smooth muscle cell.},
  author={Adrian YC Wong and Gerald A. Klassen},
  journal={Cell calcium},
  volume={14 3},
A model of smooth muscle cell is proposed to describe the mechanisms by which intracellular calcium (Cai) is regulated when the cell is stimulated by noradrenaline (NA)/agonist (Ag) or depolarized. The intracellular Ca2+ store is comprised of two calcium pools: A-store which is sensitive to inositol 1,4,5 trisphosphate (IP3) and C-store, insensitive to IP3 but sensitive to Cai. The A-store is refilled by Ca2+ from C-store and reuptake of Cai. The uptake rate is dependent on the degree of… CONTINUE READING