A model of bidirectional synaptic plasticity: from signaling network to channel conductance.

@article{Castellani2005AMO,
  title={A model of bidirectional synaptic plasticity: from signaling network to channel conductance.},
  author={Gastone C. Castellani and Elizabeth M Quinlan and F. Bersani and Leon N. Cooper and Harel Z. Shouval},
  journal={Learning & memory},
  year={2005},
  volume={12 4},
  pages={423-32}
}
In many regions of the brain, including the mammalian cortex, the strength of synaptic transmission can be bidirectionally regulated by cortical activity (synaptic plasticity). One line of evidence indicates that long-term synaptic potentiation (LTP) and long-term synaptic depression (LTD), correlate with the phosphorylation/dephosphorylation of sites on the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit protein GluR1. Bidirectional synaptic plasticity can be… CONTINUE READING