A model of BCR-FGFR1 driven human AML in immunocompromised mice.

Chromosome translocations causing aberrant activation of fibroblast growth factor receptor 1 (FGFR1) kinase in human haematopoietic stem cells leads to myeloproliferative neoplasms (MPN) that almost inevitably progress to acute myeloid leukaemia (AML)(Jackson et al, 2010). These patients, however, often also develop Tor B-lymphomas coincident with the AML… CONTINUE READING