A model for the stoichiometric regulation of blood coagulation.

  title={A model for the stoichiometric regulation of blood coagulation.},
  author={Matthew F Hockin and Kenneth C. Jones and Stephen J. Everse and Kenneth G. Mann},
  journal={The Journal of biological chemistry},
  volume={277 21},
We have developed a model of the extrinsic blood coagulation system that includes the stoichiometric anticoagulants. The model accounts for the formation, expression, and propagation of the vitamin K-dependent procoagulant complexes and extends our previous model by including: (a) the tissue factor pathway inhibitor (TFPI)-mediated inactivation of tissue factor (TF).VIIa and its product complexes; (b) the antithrombin-III (AT-III)-mediated inactivation of IIa, mIIa, factor VIIa, factor IXa, and… CONTINUE READING
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