A model for the pharmacological treatment of crouzon syndrome.

@article{Perlyn2006AMF,
  title={A model for the pharmacological treatment of crouzon syndrome.},
  author={Chad A. Perlyn and Gillian M. Morriss-Kay and T. Darvann and Marissa J. Tenenbaum and David M Ornitz},
  journal={Neurosurgery},
  year={2006},
  volume={59 1},
  pages={210-5; discussion 210-5}
}
OBJECTIVE Crouzon syndrome is caused by mutations in fibroblast growth factor receptor 2 (FGFR2) leading to constitutive activation of receptors in the absence of ligand binding. The syndrome is characterized by premature fusion of the cranial sutures that leads to abnormal cranium shape, restricted brain growth, and increased intracranial pressure. Surgical remodeling of the cranial vault is currently used to treat affected infants. The purpose of this study was to develop a pharmacological… CONTINUE READING
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