A model for the interaction of competitive antagonists with two receptor-subtypes characterized by a schild-plot with apparent slope unity

@article{Lemoine1983AMF,
  title={A model for the interaction of competitive antagonists with two receptor-subtypes characterized by a schild-plot with apparent slope unity},
  author={Horst Lemoine and Alberto Julio Kaumann},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1983},
  volume={322},
  pages={111-120}
}
1. A model is presented that predicts the double log relationship between the agonist concentration ratio \t-1 against antagonist concentration for the case of two receptor subtypes mediating the same qualitative effect of an agonist and interacting with both agonist and antagonist. The relationship is a nonlinear function which is approximated for small and high antagonist concentrations by two lines of slope 1.0 united by an inflection. The function depends on the concentration of the… CONTINUE READING
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Dissociation between stimulation and blockade (DSB) with optical isomers of pindolol on trachea and heart. The role of/~-adrenoceptor subtypes

  • M Walter, H Lemoine, AJ Kaumann
  • NaunynSchmiedeberg's Arch Pharmacol
  • 1982

Agonist-dependent enantiomeric affinity ratios of bupranolol (BU) as a tool for the differentiation of heart- and tracheal/~-adrenoceptors using 99.99 ~ optically pure (+)-bupranolol

  • H Lemoine, AJ Kaumann
  • Naunyn-Schmiedeberg's Arch Pharmacol
  • 1980
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