A model for the development of human IgD-only B cells: Genotypic analyses suggest their generation in superantigen driven immune responses.

@article{Seifert2009AMF,
  title={A model for the development of human IgD-only B cells: Genotypic analyses suggest their generation in superantigen driven immune responses.},
  author={Marc Seifert and Susanne Annette Steimle-Grauer and Tina Goossens and Martin-Leo Hansmann and Andreas Braeuninger and Ralf K{\"u}ppers},
  journal={Molecular immunology},
  year={2009},
  volume={46 4},
  pages={630-9}
}
Human peripheral blood (PB) B cells expressing only IgD and tonsillar IgD-secreting plasma cells carry highly mutated V(H) genes and show preferential Iglambda usage. To further characterize these peculiar cells and gain insight into their generation, we analysed rearranged V(H) and V(L) genes of single IgD-only lambda(+) PB B cells and IgD(+) plasma cells from four individuals each. We demonstrate that the high somatic hypermutation activity in these cells is not restricted to V(H) genes but… CONTINUE READING

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