A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von willebrand factor


Blood loss is prevented by the multidomain glycoprotein von Willebrand factor (VWF), which binds exposed collagen at damaged vessels and captures platelets. VWF is regulated by the metalloprotease ADAMTS13, which in turn is conformationally activated by VWF. To delineate the structural requirements for VWF-mediated conformational activation of ADAMTS13, we… (More)
DOI: 10.1074/jbc.AAC117.001638


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