A model for sperm-egg binding and fusion based on ADAMs and integrins.

Abstract

Once a sperm meets an egg, several events must occur in order for fertilization to proceed. Sperm must bind to the zona pellucida, undergo the acrosome reaction, penetrate the zona pellucida and then bind to and fuse with the egg plasma membrane. Shortly thereafter, the egg must be activated for zygotic development. This review focuses on mammalian sperm… (More)

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Cite this paper

@article{Bigler1997AMF, title={A model for sperm-egg binding and fusion based on ADAMs and integrins.}, author={Dennis R Bigler and M. Chen and S. Waters and J. M. White}, journal={Trends in cell biology}, year={1997}, volume={7 6}, pages={220-5} }