A model for random sampling and estimation of relative protein abundance in shotgun proteomics.

@article{Liu2004AMF,
  title={A model for random sampling and estimation of relative protein abundance in shotgun proteomics.},
  author={Hongbin Liu and Rovshan G. Sadygov and John R. Yates},
  journal={Analytical chemistry},
  year={2004},
  volume={76 14},
  pages={4193-201}
}
Proteomic analysis of complex protein mixtures using proteolytic digestion and liquid chromatography in combination with tandem mass spectrometry is a standard approach in biological studies. Data-dependent acquisition is used to automatically acquire tandem mass spectra of peptides eluting into the mass spectrometer. In more complicated mixtures, for example, whole cell lysates, data-dependent acquisition incompletely samples among the peptide ions present rather than acquiring tandem mass… CONTINUE READING
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