A model for prelingual deafness, the congenitally deaf white cat – population statistics and degenerative changes

@article{Heid1998AMF,
  title={A model for prelingual deafness, the congenitally deaf white cat – population statistics and degenerative changes},
  author={Silvia Heid and Rainer Hartmann and Rainer Klinke},
  journal={Hearing Research},
  year={1998},
  volume={115},
  pages={101-112}
}

Hearing after congenital deafness: central auditory plasticity and sensory deprivation.

The data emphasize that young sensory systems in cats have a higher capacity for plasticity than older ones and that there is a sensitive period for the cat's auditory system.

Synaptic Organization and Plasticity in the Auditory System of the Deaf White Cat

This chapter reviews the current understanding of auditory pathologies consequent to congenital deafness, highlighting observations made in the deaf white cat model and the restorative effects of electrical stimulation on the auditory system by way of cochlear implantation.

Congenital deafness affects deep layers in primary and secondary auditory cortex

Reduced layer thickness is observed in both primary and higher‐order auditory fields in layer IV and infragranular layers, but similar dystrophic effects in all investigated auditory fields are demonstrated.

Single-sided deafness leads to unilateral aural preference within an early sensitive period.

In early onset of unilateral deafness, the used ear became functionally dominant with respect to local field potential onset latency and amplitude, which explains the inferior outcome of implantations at the second- Implanted ear compared with first-implanted ear in children.

Congenital and Prolonged Adult-Onset Deafness Cause Distinct Degradations in Neural ITD Coding with Bilateral Cochlear Implants

The finding that early onset of deafness more severely degrades neural ITD coding than prolonged duration of deafhood argues for the importance of fitting deaf children with sound processors that provide reliable ITD cues at an early age.

Bilateral effects of unilateral cochlear implantation in congenitally deaf cats

It is demonstrated that electrical stimulation with a cochlear implant can help preserve central auditory synapses through direct and indirect pathways in an age‐dependent fashion.

Development of Brainstem-Evoked Responses in Congenital Auditory Deprivation

Significant postnatal subcortical development in absence of hearing, and also divergent effects of deafness on early waves II–IV and wave V of the E-ABR are demonstrated.

Functional and structural changes throughout the auditory system following congenital and early-onset deafness: implications for hearing restoration

This review attempts to summarize changes to auditory structures that often involve alteration of hair cells and supporting cells in the cochleae, and anatomical and physiological changes that extend through subcortical structures and into cortex, which are of interest to the understanding of multisensory processing.
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References

SHOWING 1-10 OF 40 REFERENCES

Histo-physiological relationships in the deaf white cat auditory system.

The first results reported here show that degeneration of sensory structures was much more advanced than physiological results lead us to believe and the possibility of direct fibre stimulation is discussed.

Primary neural disorders in the deaf white cat cochlea.

Results presented here indicate that, at least in some white cats, this assumption needs to be modified that the hereditary process of degeneration begins at the epithelial and sensory elements of the cochlea, and that the neural degeneration is only a secondary and very slow process.

Transneuronal cell atrophy in the congenitally deaf white cat

Deaf white cats with congenitally determined lesions of the organ of Corti were found to have transneuronal degeneration in the form of reduced cell size in the ventral cochlear nucleus and the

Inner ear pathology in the deafness mutant mouse.

The data suggest that the deafness gene affects the organ of Corti and that cochlear hair cells in deafness mice are never functional.