A model for mitotic inheritance of histone lysine methylation.

  title={A model for mitotic inheritance of histone lysine methylation.},
  author={Mo Xu and Weixiang Wang and She Chen and Bing Zhu},
  journal={EMBO reports},
  volume={13 1},
Histone lysine methylation has been implicated in epigenetic regulation of transcription. Using stable-isotope labelling and quantitative mass spectrometry, we analysed the dynamics of histone lysine methylation. Here we report that histone methylation levels are transiently reduced during S phase and are gradually re-established during subsequent cell cycle stages. However, despite the recovery of overall methylation levels before the next S phase, the methylation levels of parental and newly… CONTINUE READING


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