A model for human cardiac troponin C and for modulation of its Ca2+ affinity by drugs.

@article{Ovaska1991AMF,
  title={A model for human cardiac troponin C and for modulation of its Ca2+ affinity by drugs.},
  author={Martti Ovaska and Jyrki Taskinen},
  journal={Proteins},
  year={1991},
  volume={11 2},
  pages={79-94}
}
Calcium sensitizers are drugs which increase force development in striated muscle by sensitizing myofilaments to Ca2+. This can happen by increasing Ca2+ affinity of the regulatory domain of Ca2+ binding protein troponin C. High resolution crystal structures of two calcium binding proteins, calmodulin (Babu et al.: J. Mol. Biol. 203:191-204, 1988) and skeletal troponin C (Satyshur et al.: J. Biol. Chem. 263:1628-1647, 1988; Herzber et al.: J. Mol. Biol. 203:761-779, 1988), have recently been… CONTINUE READING

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