A model for distinguishing between beta1-receptors which mediate a specific effect on the heart rate and those which mediate a positively inotropic effect.

@article{Bonelli1977AMF,
  title={A model for distinguishing between beta1-receptors which mediate a specific effect on the heart rate and those which mediate a positively inotropic effect.},
  author={J A Bonelli and Dieter Magometschnigg and Gerhart Hitzenberger and G. Kaik},
  journal={International journal of clinical pharmacology and biopharmacy},
  year={1977},
  volume={15 8},
  pages={
          381-3
        }
}
The study was conducted in six healthy male volunteers aged between 20 and 30 years. Cardiac output was determined by means of the Swan-Ganz-thermodilution-method. A control-study was carried out, during which an isoproterenolinfusion with increasing doses was given. Fifty minutes after i.v. injection of a beta-receptor-blocker the hemodynamic parameters were measured again under increasing doses of isoproterenol until the block was overcome. This study procedure was performed twice in each… CONTINUE READING

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