A model for circadian oscillations in the Drosophila period protein (PER)

@article{Goldbeter1995AMF,
  title={A model for circadian oscillations in the Drosophila period protein (PER)},
  author={Albert Goldbeter},
  journal={Proceedings of the Royal Society of London. Series B: Biological Sciences},
  year={1995},
  volume={261},
  pages={319 - 324}
}
  • A. Goldbeter
  • Published 22 September 1995
  • Biology
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
The mechanism of circadian oscillations in the period protein (PER) in Drosophila is investigated by means of a theoretical model. Taking into account recent experimental observations, the model for the circadian clock is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period (per) gene. This minimal biochemical model provides a molecular basis for circadian oscillations of the limit cycle type. During oscillations, the peak in… 

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References

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TLDR
Results indicate that the per feedback loop has all of the basic properties necessary to be a component of a circadian oscillator.
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TLDR
Results indicate that the autoregulation of per expression is a direct, intracellular event and suggest that each per‐expressing cell contains an autonomous oscillator of which the per feedback loop is a component.
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TLDR
It is suggested that the phosphorylation status of PER is an important determinant in the Drosophila clock's time-keeping mechanism.
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TLDR
It is suggested that perl and pers mutants produce hypoactive and hyperactive per proteins, respectively, which are inversely correlated with period length, so that flies with lowest levels of the per product have slow-running biological clocks.
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TLDR
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TLDR
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TLDR
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