A model for circadian oscillations in the Drosophila period protein (PER)

@article{Goldbeter1995AMF,
  title={A model for circadian oscillations in the Drosophila period protein (PER)},
  author={A. Goldbeter},
  journal={Proceedings of the Royal Society of London. Series B: Biological Sciences},
  year={1995},
  volume={261},
  pages={319 - 324}
}
  • A. Goldbeter
  • Published 1995
  • Medicine, Biology
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
  • The mechanism of circadian oscillations in the period protein (PER) in Drosophila is investigated by means of a theoretical model. Taking into account recent experimental observations, the model for the circadian clock is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period (per) gene. This minimal biochemical model provides a molecular basis for circadian oscillations of the limit cycle type. During oscillations, the peak in… CONTINUE READING

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