A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

@article{Hensley1994AMF,
  title={A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.},
  author={Kenneth Hensley and John M. Carney and Mark P. Mattson and Marina V. Aksenova and Meera E Harris and Jing Feng Wu and Robert A. Floyd and David Butterfield},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 8},
  pages={3270-4}
}
beta-Amyloid is a 39- to 43-amino-acid neurotoxic peptide that aggregates to form the core of Alzheimer disease-associated senile (amyloid) plaques. No satisfactory hypothesis has yet been proposed to explain the mechanism of beta-amyloid aggregation and toxicity. We present mass spectrometric and electron paramagnetic resonance spin trapping evidence that beta-amyloid, in aqueous solution, fragments and generates free radical peptides. beta-Amyloid fragments, at concentrations that previously… CONTINUE READING
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Biochemistry 31 , 12277 - 12288

  • S. B. Prusiner
  • Proc . Natl . Acad Sci . USA
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