A model-based method for assessing insulin sensitivity from the oral glucose tolerance test.

@article{Mari2001AMM,
  title={A model-based method for assessing insulin sensitivity from the oral glucose tolerance test.},
  author={Andrea Mari and Giovanni Pacini and Eleanor Murphy and Bernhard Ludvik and John J. Nolan},
  journal={Diabetes care},
  year={2001},
  volume={24 3},
  pages={539-48}
}
OBJECTIVE Available insulin sensitivity (IS) methods based on the oral glucose tolerance test (OGTT) are empirical. We used a glucose-insulin model to derive an OGTT-based IS (oral glucose insulin sensitivity [OGIS]) index, which predicts glucose clearance in a glucose clamp. We validated OGIS against clamp data. RESEARCH DESIGN AND METHODS OGIS requires glucose and insulin concentrations from a 75-g OGTT at 0, 2, and 3 h (3-h OGTT) or at 0, 1.5, and 2 h (2-h OGTT). The formula includes six… CONTINUE READING
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