A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens

@article{Elsherbiny2008AMB,
  title={A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens},
  author={Doaa A. Elsherbiny and Sara A. Asimus and Mats O. Karlsson and Michael Ashton and Ulrika S H Simonsson},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2008},
  volume={35},
  pages={203-217}
}
The study aim was to assess the inductive properties of artemisinin antimalarials using mephenytoin as a probe for CYP2B6 and CYP2C19 enzymatic activity. The population pharmacokinetics of S-mephenytoin and its metabolites S-nirvanol and S-’-hydroxymephenytoin, including enzyme turn-over models for induction, were described by nonlinear mixed effects modeling. Rich data (8–16 samples/occasion/subject) were collected from 14 healthy volunteers who received mephenytoin before and during ten days… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

on ACTs (Artemisinin-based Combination Therapies)

  • WHO. Fact
  • 2006 [cited 7 December
  • 2007
1 Excerpt

The Visual predictive check—superiority to standard diagnostic (Rorschach) Plots

  • N Holford
  • Available from: http://www.page-meetingorg…
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…