• DOI:10.1111/bcp.12897
Corpus ID: 3582267

A model-based approach to assess the exposure-response relationship of Lorenzo's oil in adrenoleukodystrophy.

@article{Ahmed2016AMA,
  title={A model-based approach to assess the exposure-response relationship of Lorenzo's oil in adrenoleukodystrophy.},
  author={M. Ahmed and R. Kartha and R. Brundage and J. Cloyd and C. Basu and B. Carlin and R. Jones and A. Moser and A. Fatemi and G. Raymond},
  journal={British journal of clinical pharmacology},
  year={2016},
  volume={81 6},
  pages={
          1058-66
        }
}

M. Ahmed, R. Kartha, +7 authors G. Raymond

Published 2016

Medicine

British journal of clinical pharmacology

AIMS X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder, most commonly affecting boys, associated with increased very long chain fatty acids (C26:0) in all tissues, causing cerebral demyelination and adrenocortical insufficiency. Certain monounsaturated long chain fatty acids including oleic and erucic acids, known as Lorenzo's oil (LO), lower plasma C26:0 levels. The aims of this study were to characterize the effect of LO administration on plasma C26:0 concentrations and to… CONTINUE READING

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