A mixture of anatase and rutile TiO2 nanoparticles induces histamine secretion in mast cells

@inproceedings{Chen2011AMO,
  title={A mixture of anatase and rutile TiO2 nanoparticles induces histamine secretion in mast cells},
  author={Eric Y. T. Chen and Mar{\'i}a Bel{\'e}n Garnica and Yung-Chen Wang and Alexander J Mintz and Chi-shuo Chen and Wei-Chun Chin},
  booktitle={Particle and Fibre Toxicology},
  year={2011}
}
BackgroundHistamine released from mast cells, through complex interactions involving the binding of IgE to FcεRI receptors and the subsequent intracellular Ca2+ signaling, can mediate many allergic/inflammatory responses. The possibility of titanium dioxide nanoparticles (TiO2 NPs), a nanomaterial pervasively used in nanotechnology and pharmaceutical industries, to directly induce histamine secretion without prior allergen sensitization has remained uncertain.ResultsTiO2 NP exposure increased… CONTINUE READING

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