A mitotically inheritable unit containing a MAP kinase module.

  title={A mitotically inheritable unit containing a MAP kinase module.},
  author={S{\'e}bastien Kicka and Crystel Bonnet and Andrew K. Sobering and Latha P Ganesan and Philippe Silar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 36},
Prions are novel kinds of hereditary units, relying solely on proteins, that are infectious and inherited in a non-Mendelian fashion. To date, they are either based on autocatalytic modification of a 3D conformation or on autocatalytic cleavage. Here, we provide further evidence that in the filamentous fungus Podospora anserina, a MAP kinase cascade is probably able to self-activate and generate C, a hereditary unit that bears many similarities to prions and triggers cell degeneration. We show… CONTINUE READING