A mitogenic signal triggered at an early stage of vaccinia virus infection: implication of MEK/ERK and protein kinase A in virus multiplication.

@article{Magalhes2001AMS,
  title={A mitogenic signal triggered at an early stage of vaccinia virus infection: implication of MEK/ERK and protein kinase A in virus multiplication.},
  author={J C de Magalh{\~a}es and Anderson Assunç{\~a}o Andrade and Patricia Gisela Silva and Lirl{\^a}ndia P Sousa and Catherine Ropert and Paulo Ferreira and Erna Geessien Kroon and Ricardo Tostes Gazzinelli and Cl{\'a}udio A Bonjardim},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 42},
  pages={
          38353-60
        }
}
Vaccinia virus (VV) triggers a mitogenic signal at an early stage of infection. VV-induced proto-oncogene c-fos mRNA with kinetics paralleling that stimulated by serum. The VV virokine, or vaccinia virus growth factor (VGF), was not crucial for c-fos induction because it was observed upon infection with the virokine-minus mutant VV (VGF(-)). Furthermore, c-fos expression did not require infectious virus particles, as it occurred even with UV-inactivated VV and was equally induced by the… CONTINUE READING

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