A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation.

@article{Shan2014AMP,
  title={A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation.},
  author={Jixiu Shan and Mukundh N Balasubramanian and William Donelan and Lingchen Fu and Jaclyn N. Hayner and M Cecilia Lopez and Henry V Baker and Michael S. Kilberg},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 35},
  pages={24665-79}
}
Amino acid (AA) limitation in mammalian cells triggers a collection of signaling cascades jointly referred to as the AA response (AAR). In human HepG2 hepatocellular carcinoma, the early growth response 1 (EGR1) gene was induced by either AA deprivation or endoplasmic reticulum stress. AAR-dependent EGR1 activation was discovered to be independent of the well characterized GCN2-ATF4 pathway and instead dependent on MEK-ERK signaling, one of the MAPK pathways. ChIP showed that constitutively… CONTINUE READING

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