A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity.

@article{Law2006AMT,
  title={A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity.},
  author={Benedict Law and Luisa Quinti and Yongdoo Choi and Ralph Weissleder and Ching-Hsuan Tung},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 8},
  pages={1944-9}
}
A potent cytotoxic peptide (r7-kla) was synthesized by incorporating a mitochondrial membrane disrupting peptide, kla (klaklakklaklak), with a cell-penetrating domain, r7 (rrrrrrr). The IC(50) of r7-kla (3.54 +/- 0.11 micromol/L) was more than two orders of magnitude lower than that of kla. r7-kla induced cell death in both in vitro and in vivo environments, and showed rapid kinetics. Within minutes, the morphologic changes in cells and mitochondrial leakage were apparent by microscopy and was… CONTINUE READING
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