A mitochondrial superoxide theory for oxidative stress diseases and aging

@inproceedings{Indo2015AMS,
  title={A mitochondrial superoxide theory for oxidative stress diseases and aging},
  author={Hiroko P. Indo and Hsiu-chuan Yen and Ikuo Nakanishi and Ken-ichiro Matsumoto and Masato Tamura and Yumiko N Nagano and Hirofumi Matsui and Oleg Gusev and Richard Cornette and Takashi Okuda and Yukiko Minamiyama and Hiroshi Ichikawa and Shigeaki Suenaga and Misato Oki and Tsuyoshi Sato and Toshihiko Ozawa and Daret K. St. Clair and Hideyuki J. Majima},
  booktitle={Journal of clinical biochemistry and nutrition},
  year={2015}
}
Fridovich identified CuZnSOD in 1969 and manganese superoxide dismutase (MnSOD) in 1973, and proposed "the Superoxide Theory," which postulates that superoxide (O2 (•-)) is the origin of most reactive oxygen species (ROS) and that it undergoes a chain reaction in a cell, playing a central role in the ROS producing system. Increased oxidative stress on an organism causes damage to cells, the smallest constituent unit of an organism, which can lead to the onset of a variety of chronic diseases… CONTINUE READING