A mitochondrial pyruvate dehydrogenase bypass in the yeast Saccharomyces cerevisiae.

@article{Boubekeur1999AMP,
  title={A mitochondrial pyruvate dehydrogenase bypass in the yeast Saccharomyces cerevisiae.},
  author={Samira Boubekeur and Odile Bunoust and Nadine Camougrand and Michel Castroviejo and Michel Rigoulet and Bernard Gu{\'e}rin},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 30},
  pages={
          21044-8
        }
}
Spheroplasts of the yeast Saccharomyces cerevisiae oxidize pyruvate at a high respiratory rate, whereas isolated mitochondria do not unless malate is added. We show that a cytosolic factor, pyruvate decarboxylase, is required for the non-malate-dependent oxidation of pyruvate by mitochondria. In pyruvate decarboxylase-negative mutants, the oxidation of pyruvate by permeabilized spheroplasts was abolished. In contrast, deletion of the gene (PDA1) encoding the E1alpha subunit of the pyruvate… CONTINUE READING

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