A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.

@article{Uboldi2006AMP,
  title={A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.},
  author={Alessandro D. Uboldi and Franziska B Lueder and Peter Walsh and Timothy P. Spurck and Geoffrey Ian McFadden and J. Curtis and Vladimir A. Likic and Matthew A. Perugini and Mary Barson and Trevor Lithgow and Emanuela Handman},
  journal={International journal for parasitology},
  year={2006},
  volume={36 14},
  pages={
          1499-514
        }
}
The single mitochondrion of kinetoplastids divides in synchrony with the nucleus and plays a crucial role in cell division. However, despite its importance and potential as a drug target, the mechanism of mitochondrial division and segregation and the molecules involved are only partly understood. In our quest to identify novel mitochondrial proteins in Leishmania, we constructed a hidden Markov model from the targeting motifs of known mitochondrial proteins as a tool to search the Leishmania… CONTINUE READING
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