A mitochondrial bottleneck hypothesis of Alzheimer's disease.

  title={A mitochondrial bottleneck hypothesis of Alzheimer's disease.},
  author={James N. Davis and E J Hunnicutt and Jane C. Chisholm},
  journal={Molecular medicine today},
  volume={1 5},
Alzheimer's disease, in its early onset familial form, is known to be a heterogeneous disorder. This suggests that the different degenerative mechanisms, initiated by different genetic causes and ending in the shared phenotype of the disease, should intersect at some point in the degenerative cascade to form a 'bottleneck' from which the pathological features that are common to each of the genetic forms emerge. A growing body of evidence suggests that disturbances of energy metabolism may play… CONTINUE READING

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