A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

@article{Mohrin2015AMU,
  title={A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging},
  author={Mary Mohrin and Jiyung Shin and Yufei Liu and Katharine V Brown and Hanzhi Luo and Yannan Xi and Cole M. Haynes and Danica Chen},
  journal={Science},
  year={2015},
  volume={347},
  pages={1374-1377}
}
Deterioration of adult stem cells accounts for much of aging-associated compromised tissue maintenance. How stem cells maintain metabolic homeostasis remains elusive. Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPRmt), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation. SIRT7 inactivation caused reduced quiescence, increased mitochondrial protein folding stress (PFSmt), and compromised… CONTINUE READING
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