A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

@article{Bonnet2007AMC,
  title={A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.},
  author={S{\'e}bastien Bonnet and Stephen L Archer and Joan Allalunis-Turner and Alois Haromy and Christian Beaulieu and Richard E. Thompson and Christopher T. Lee and Gary D Lopaschuk and Lakshmi Puttagunta and Sandra N Bonnet and Gwyneth I. Harry and Kyoko Hashimoto and Christopher J Porter and Miguel A Andrade and Bernard Th{\'e}baud and Evangelos D Michelakis},
  journal={Cancer cell},
  year={2007},
  volume={11 1},
  pages={37-51}
}
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted. Compared to normal cells, several human cancers have high mitochondrial membrane potential (DeltaPsim) and low expression of the K+ channel Kv1.5, both contributing to apoptosis resistance. Dichloroacetate (DCA) inhibits mitochondrial pyruvate dehydrogenase kinase (PDK), shifts metabolism from glycolysis to glucose oxidation, decreases DeltaPsim, increases mitochondrial… CONTINUE READING
Highly Influential
This paper has highly influenced 72 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 82 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 600 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

In vivo gene transfer

  • Z. I. Pozeg, E. D. Michelakis, +7 authors G Harry
  • 2003
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…