A missing link in body weight homeostasis: the catabolic signal of the overfed state.

@article{Ravussin2014AML,
  title={A missing link in body weight homeostasis: the catabolic signal of the overfed state.},
  author={Yann Ravussin and Rudolph L. Leibel and Anthony W. Ferrante},
  journal={Cell metabolism},
  year={2014},
  volume={20 4},
  pages={565-72}
}
Mammals regulate fat mass so that increases or reductions in adipose tissue mass activate responses that favor return to one's previous weight. A reduction in fat mass activates a system that increases food intake and reduces energy expenditure; conversely, overfeeding and rapid adipose tissue expansion reduces food intake and increases energy expenditure. With the identification of leptin nearly two decades ago, the central circuit that defends against reductions in body fat was revealed… CONTINUE READING