A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers.

@article{Ahmad1998AMM,
  title={A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers.},
  author={Wasim Ahmad and Alan D Irvine and Hon Wai Lam and Cameron Buckley and Elizabeth A Bingham and Andrey A Panteleyev and M. Ahmad and J A McGrath and Angela M. Christiano},
  journal={American journal of human genetics},
  year={1998},
  volume={63 4},
  pages={984-91}
}
Congenital atrichia is a rare, recessively inherited form of hair loss affecting both males and females and is characterized by a complete absence of hair follicles. Recently, a mutation in the human hairless gene was implicated in the pathogenesis of congenital atrichia. The human hairless gene encodes a putative single zinc-finger transcription-factor protein with restricted expression in brain and skin, which is believed to regulate catagen remodeling in the hair cycle. In this study, we… CONTINUE READING

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