A missense mutation in the gene for melanocyte-stimulating hormone receptor (MCIR) is associated with the chestnut coat color in horses

@article{Marklund1996AMM,
  title={A missense mutation in the gene for melanocyte-stimulating hormone receptor (MCIR) is associated with the chestnut coat color in horses},
  author={Lena Marklund and M. Johansson Moller and Kaj Sandberg and Leif Andersson},
  journal={Mammalian Genome},
  year={1996},
  volume={7},
  pages={895-899}
}
The melanocyte-stimulating hormone receptor gene (MCIR) is the major candidate gene for the chestnut coat color in horses since it is assumed to be controlled by an allele at the extension locus. MCIR sequences were PCR amplified from chestnut (e/e) and non-chestnut (EI-) horses. A single-strand conformation polymorphism was found that showed a complete association to the chestnut coat color among 144 horses representing 12 breeds. Sequence analysis revealed a single missense mutation (83Ser… CONTINUE READING
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