A minor groove RNA triple helix within the catalytic core of a group I intron

@article{Szewczak1998AMG,
  title={A minor groove RNA triple helix within the catalytic core of a group I intron},
  author={Alexander A. Szewczak and Lori Ortoleva-Donnelly and Sean P. Ryder and Eileen Moncoeur and Scott A Strobel},
  journal={Nature Structural Biology},
  year={1998},
  volume={5},
  pages={1037-1042}
}
Close packing of several double helical and single stranded RNA elements is required for the Tetrahymena group I ribozyme to achieve catalysis. The chemical basis of these packing interactions is largely unknown. Using nucleotide analog interference suppression (NAIS), we demonstrate that the P1 substrate helix and J8/7 single stranded segment form an extended minor groove triple helix within the catalytic core of the ribozyme. Because each triple in the complex is mediated by at least one 2… CONTINUE READING

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