A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.

Abstract

BACKGROUND Na(+)/H(+) exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial… (More)
DOI: 10.5507/bp.2015.060

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