A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures.

@article{Taha2013AMO,
  title={A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures.},
  author={Ameer Y Taha and Marc-Olivier Tr{\'e}panier and Flaviu A Ciobanu and Nadeen M Y Taha and Muaz Ahmed and Qiudi H Zeng and Waiyin I Cheuk and Bryan Ip and Elvis Filo and Brian W. Scott and W. McIntyre Burnham and Richard P. Bazinet},
  journal={Epilepsy & behavior : E&B},
  year={2013},
  volume={27 1},
  pages={49-58}
}
Complex partial seizures, which typically originate in limbic structures such as the amygdala, are often resistant to antiseizure medications. Our goal was to investigate the effects of chronic dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs) derived from fish oil on seizure thresholds in the amygdala, as well as on blood and brain PUFA levels. The acute effects of injected n-3 PUFAs--eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)--were also tested in the maximal… CONTINUE READING

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