A minimal-model-based glucose clamp yielding insulin sensitivity independent of glycemia.

@article{Pacini1982AMG,
  title={A minimal-model-based glucose clamp yielding insulin sensitivity independent of glycemia.},
  author={Giovanni Pacini and Diane T. Finegood and Richard N Bergman},
  journal={Diabetes},
  year={1982},
  volume={31 5 Pt 1},
  pages={432-41}
}
A new technique is introduced for automatic control of the blood sugar ("glucose clamp") at basal (euglycemic) or elevated (hyperglycemic) levels during variable insulin infusion. A minimal mathematical model of glucose kinetics is implemented on a laboratory minicomputer during clamp experiments. From the measured time course of plasma glucose concentration, the computer estimates the fractional disappearance rate of glucose (X) and calculates the rate of exogenous infusion required to match… CONTINUE READING