A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units.

@article{Westerhoff1984AMH,
  title={A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units.},
  author={Hans V. Westerhoff and Bruno Andrea Melandri and G. Van Brakel A. R. Varga G. Venturoli and Giovanni Felice Azzone and Douglas B. Kell},
  journal={Biochimica et biophysica acta},
  year={1984},
  volume={768 3-4},
  pages={257-92}
}
Experimental data are reviewed that are not in keeping with the scheme of 'delocalized' protonic coupling in membrane-linked free-energy transduction. It turns out that there are three main types of anomalies: (i) rates of electron transfer and of ATP synthesis do not solely depend on their own driving force and on delta mu H, (ii) the ('static head') ratio of delta Gp to delta mu H varies with delta mu H and (iii) inhibition of either some of the electron-transfer chains or some of the H… CONTINUE READING

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A Inaccessibility of the proton pumps towards their scalar substrates The capacitance of the proton domains is too low to account for the observed free-energy stores

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C. Acid-base phosphorylation

  • C. Acid-base phosphorylation

To whom correspondence should be addressed at the Laboratory of Molecular Biology, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases

  • National Institutes of Health, Building

VIII. Objections against the coupling-unit hypothesis

  • VIII. Objections against the coupling-unit…

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