A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases.

@article{Pham2007AMT,
  title={A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases.},
  author={Yen Bao Pham and Li Li and Aram Kim and Ozgun Erdogan and Violetta Weinreb and Glenn L. Butterfoss and Brian Kuhlman and Charles W. Carter},
  journal={Molecular cell},
  year={2007},
  volume={25 6},
  pages={851-62}
}
The emergence of polypeptide catalysts for amino acid activation, the slowest step in protein synthesis, poses a significant puzzle associated with the origin of biology. This problem is compounded as the 20 contemporary aminoacyl-tRNA synthetases belong to two quite distinct families. We describe here the use of protein design to show experimentally that a minimal class I aminoacyl-tRNA synthetase active site might have functioned in the distant past. We deleted the anticodon binding domain… CONTINUE READING

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